Lubricant Article
Vaginal lubricants can damage sperm
Source: 47th annual meeting of the American Society for Therapeutic Radiology and Oncology; Denver, Colorado, USA: 16-20 October 2005
Researchers demonstrate damage to sperm with vaginal lubricants commonly recommended to fertility patients.
Vaginal lubricants frequently recommended to fertility patients may be damaging sperm quality, research suggests.
The experiments demonstrated significant reductions in sperm motility and significant damage to sperm DNA with all but one of the four brands of vaginal lubricant studied.
Dr. Ashok Agarwal, from the Cleveland Clinic in Ohio, USA, and his team tested the effect on sperm motility of incubation with medium containing 10 percent of Pre-Seed, FemGlide, Replens or Astroglide. Sperm from normal donors was also incubated with lubricant-free medium to provide a control.
After 30-minute incubation, sperm motility ranged from 66 percent in control medium to just 2 percent in medium containing Astroglide. At 64 percent motility, Pre-Seed had the least impact on motility, the researchers note.
Chromatin damage caused by the lubricants was assessed in a second series of experiments. For these, donor sperm were incubated for 4 hours with medium containing Pre-Seed- or FemGlide, lubricant-free medium, or KY, which served as a negative control.
Pre-Seed was the only lubricant that did not cause significant damage to genetic material, with just 7 percent more chromatin damage seen in sperm exposed to this lubricant than in that incubated in the control medium, as assessed by the DNA fragmentation index.
Posted: 25 October 2005
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