I had the methotrexate because I had retained placental tissue after my ectopic. (I had surgery but the embreyo had aborted out the end of the tube, so, I didn't have to have it removed.) Therefore, my experience proabably isn't typical. I was already bleeding but the cramping and bleeding got worse about 2 days after my shot. I would give your doc a call though if you're at all concerned. Better safe than sorry. Good luck and I'm sorry you have to deal with an ectopic.

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